I think Cotto would give him a hard time but stats point to Mayweather winning this bout. Think about it, Cotto does not stop coming forward and Mayweather does not stop going backwards, so the ropes would be a problem for Weather as always, yet the open ring would be a problem for Cotto.
All it takes is one nice punch from either of them to win the fight. Left hooks from either fighter are deadly with Mayweather headhunting and Cotto being the bodysnatcher he is...
Good fight but I see Cotto getting hit in the head a lot!